Table 1.
Stimulatory effect of atorvastatin and celecoxib alone or in combination on apoptosis in LNCaP cells
| Treatment | % Apoptotic cells | Fold increase* |
|---|---|---|
| Regular medium | ||
| Control | 1.9±0.2 | – |
| Atorvastatin (10 μM) | 12.3±0.5 | 6.5 |
| Celecoxib (10 μM) | 15.1±0.6 | 7.9 |
| Atorvastatin (10 μM) + Celecoxib (10 μM) | 33.4±2.5 | 17.6 |
| Androgen-depleted medium | ||
| Control | 9.0±0.2 | 4.7 |
| Atorvastatin (10 μM) | 22.5±1.4 | 11.8 |
| Celecoxib (10 μM) | 27.8±2.0 | 14.6 |
| Atorvastatin (10 μM) + Celecoxib (10 μM) | 62.2±4.1 | 32.7 |
LNCaP cells were seeded at a density of 5×104 cells/ml in cell culture dishes and incubated in regular or androgen-depleted medium. The cells were treated with atorvastatin (10 μM) and celecoxib (10 μM) alone or in combination for 96 h. Apoptotic cells were determined by morphological assessment. Each value represents the mean ± S.E. from three experiments.
*
Fold-increase when compared with control cells grown in regular medium.