Table 6.

Comparison of manual and automated IHC scores given in Tables 4 and 5

Comparison	Correlation coefficient	Mean difference	95% CI	p value (paired t-test)
PS vs PSA (HIF)	0.94	0.13	(0.05,0.22)	0.01
PS vs PSA (VEGF)	0.89	0.02	(−0.07,0.11)	0.63
PS*IS vs AMI (HIF)	0.92	−0.05	(−0.16,0.06)	0.29
PS*IS vs AMI (VEGF)	0.93	−0.06	(−0.22,0.09)	0.38

The second column indicates the correlation coefficient computed between manual and automated scores (n=10). The third column shows the average difference between manual and automated scores. The fourth column shows the 95% confidence interval (CI) for the average difference. The last column presents the p value of a two-sample t-test for the average difference, with usual significance being less than 0.05. AMI, automated mean intensity.