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. 2009 May 15;20(2):282–293. doi: 10.1093/cercor/bhp097

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© 2009 The Authors

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Neurochemical specificity of ME20.4-saporin injections. (a) Parvalbumin-stained section through the left temporal lobe of case CON2. The small box in the MTG shows the approximate location of the higher power images (b–g). This region was chosen for illustration because it is the area of maximal cholinergic depletion. (b, c) Parvalbumin immunohistochemistry in cases ACh2 (b) and CON2 (c) shows intact parvalbumin-immunoreactive neurons in the lesion case. (d, e) TH immunohistochemistry in cases ACh2 (d) and CON2 (e) shows intact TH-immunoreactive (presumably dopaminergic and noradrenergic) fibers in the lesion case. (f, g) Serotonin transporter (5HTT) immunohistochemistry in cases ACh2 (f) and CON2 (g) shows intact 5HTT-immunoreactive (presumably serotonergic) fibers in the lesion case. The scale bar in (b) is 0.1 mm and applies to panels (b–g).