Table 2.
Crude, annualised mortality rates and hazard ratios within treatment groups by occurrence of hypoglycaemia
| Mortality rate (n=451 deaths) | Hazard ratio for no previous events v at least one event, stratified by glycaemia arm* (HR (95% CI)) | ||
|---|---|---|---|
| No previous events | At least one previous event | ||
| Hypoglycaemic events requiring any assistance, medical or non-medical (HA)† | |||
| Intensive | 1.2% a year (201 deaths/16 315 person years) |
2.8% a year (53 deaths/1924 person years) |
Unadj: 1.79 (1.32 to 2.44) Adj: 1.41 (1.03 to 1.93) |
| Standard | 1.0% a year (176 deaths/17 297 person years) |
3.7% a year (21 deaths/564 person years) |
Unadj: 2.93 (1.86 to 4.63) Adj: 2.30 (1.46 to 3.65) |
| Hypoglycaemic events requiring medical assistance (HMA)‡ | |||
| Intensive | 1.3% a year (220 deaths/17 031 person years) |
2.8% a year (34 deaths/1208 person years) |
Unadj: 1.72 (1.19 to 2.47) Adj: 1.28 (0.88 to 1.85) |
| Standard | 1.0% a year (180 deaths/17 516 person years) |
4.9% a year (17 deaths/345 person years) |
Unadj: 3.88 (2.35 to 6.40) Adj: 2.87 (1.73 to 4.76) |
*Adjusted hazard ratios are adjusted for the following baseline covariates: age, gender, smoking status, history of cardiovascular disease, history of heart failure, peripheral neuropathy, albumin to creatinine ratio, heart rate, QT score (from electrocardiology), visual acuity score, statin use, sulfonylurea use, glycaemia intervention, enrolled in lipid v blood pressure trial, intensive blood pressure control group, and fibrate group.
†P=0.076 for interaction between history of hypoglycaemia requiring any assistance and glycaemia intervention.
‡P=0.009 for interaction between history of hypoglycaemia requiring medical assistance and glycaemia intervention.