Table 3.
p53 Mutations in Lung Neoplasms of B6C3F1 Mice in a 2-Year Inhalation Study of Cumenea
| Treatment ppm | Activate p53b(%) | IHC Positive No. (%) | Exon5 | Exon7 |
|---|---|---|---|---|
| Control | 0/7 (0) | 1/7 (14) | 0 | 0 |
| Cumene | 27/52 (52) | 29/52 (56) | 24 | 3 |
| 125 | 0/4 (0) | 1/4 (25) | 0 | 0 |
| 250 | 5/13 (38) | 6/13 (46) | 4 | 1 |
| 500 | 11/18 (38) | 8/18 (44) | 10 | 1 |
| 1000 | 11/17 (65) | 14/17 (82) | 10 | 1 |
a
Male and female B6C3F1 mice were exposed to 0, 125 (females only), 250, 500, or 1000 (males only) ppm cumene by whole-body inhalation, 6hr./day, 5 days/week for 2 years.
b
No mutation detected for p53 at exons 6 & 8 in the samples examined.