Table 1.
Significant pathways from top 250 predictor genes associated with response to PG-11047 treatment using Ingenuity Pathway analysis.
| Pathway Name | P-Value | Ratio | Component genes in the pathway |
|---|---|---|---|
| Interferon Signaling | 0.001 | [4/29] | IRF1, IRF9, TAP1, IFNGR1 |
| Ephrin Receptor Signaling | 0.011 | [8/193] |
CXCR4, ABI1, RAP1A, MAPK1, WASL, MAP4K4, GNAI3, PAK1 |
| Role of BRCA1 in DNA Damage Response |
0.013 | [4/52] | RPA1, RFC3, MSH2, E2F3 |
| Nicotinate and Nicotinamide Metabolism |
0.019 | [5/129] | NNMT, ENPP2, MAPK1, ENPP1, PAK1 |
| Fcy Receptor -mediatedPhagocytosis in Macrophages andMonocytes | 0.028 | [5/104] | RPS6KB1, LYN, MAPK1, VAMP3, PAK1 |
| Riboflavin Metabolism | 0.032 | [2/49] | ENPP2, ENPP1 |
| Endoplasmic Reticulum Stress Pathway |
0.041 | [2/18] | XBP1, TAOK3 |
| Pantothenateand CoA Biosynthesis | 0.046 | [2/63] | ENPP2, ENPP1 |
| CXCR4 Signaling | 0.052 | [6/164] | CXCR4, RHOB, LYN, MAPK1, GNAI3, PAK1 |
| PI3K/AKT Signaling | 0.055 | [5/135] | RPS6KB1, SFN, MAPK1, YWHAH, PPP2R5A |
| Integrin Signaling | 0.056 | [7/198] | RHOB, RAP1A, MAPK1, TSPAN6, WASL, ARF4, PAK1 |
Ratio indicates the number of genes in the top 250 predictors that belong to the pathway indicated over the number of genes known of the pathway. Genes in bold were associated with resistance when transcribed at high levels. Genes in normal fonts were associated with sensitivity when transcribed at high levels.