Table 3.
Clinical results of Shigella infections between 1995 and 2008.
| A (1995 - 1996) | B (2000 - 2002) | C (2007 - 2008) | Combined | p valuea | |
|---|---|---|---|---|---|
| Pateints | n = 63 | n = 113 | n = 103 | n = 279 | |
| Age (months)d | 23 (17 - 48) | 21 (14 - 29) | 30 (19 - 42) | 24 (16 - 36) | < 0.001 |
| Weight (kg) | 10 (9 - 13) | 10 (9 - 12) | 11.5 (10 - 15) | 10.5 (9 - 13) | 0.004 |
| Male sex (%) | 31 (49) | 50 (44) | 61 (59) | 184 (59%) | 0.085 |
| Patient history | |||||
| Days | 2 (1 - 7) | 2 (1 - 9) | 1 (1 - 4) | 2 (1 - 9) | < 0.001 |
| Fever (%) | 62 (98) | 104 (92) | 100 (97) | 266 (95) | 0.09 |
| Abdominal pain (%) | 33 (52) | 41 (36) | 79 (76) | 153 (54) | < 0.001 |
| Vomitting (%) | 24 (38) | 64 (56) | 51 (49) | 139 (50) | 0.062 |
| Watery diarrhea (%) | 28 (44) | 67 (59) | 74 (71) | 169 (60) | 0.002 |
| Bloody/mucoid diarrhea (%) | 63 (100) | 60 (53) | 98 (95) | 221 (79) | < 0.001 |
| Diahorreal episodes per day | NA | 8 (5-10) | 8 (5-10) | 8 (5-10) | 0.595 |
| Convulsions (%) | 4 (6) | 7 (6) | 20 (19.4) | 31 (11) | < 0.001 |
| Known pretreatment (%) | 3 (5) | 8 (7) | 4 (4) | 14 (5) | 0.543 |
| Clinical details | |||||
| Serotype sonnei (%) | 21/63 (33) | 55/113 (49) | 71/103 (69) | 153/279 (55) | < 0.001 |
| White cell count (× 103/mm3) | 10 (8.3 - 15) | 10.1 (7.7 - 12.8) | 13.1 (10.1 - 17.3) | 11.3 (8.7 - 15.4) | < 0.001 |
| Red cells in stoolb | NA | 1 | 1 | 1 | 0.715 |
| White cells in stoolb | NA | 3 | 3 | 3 | 0.02 |
| Mucoid duration (hrs) | 31.5 (24 - 53.5) | 36 (24 - 54) | 28 (18 - 48) | 30 (19.5 - 48) | 0.113 |
| Diarrhea duration (hrs) | 48.5 (29.25 - 87) | 48 (24 - 72) | 48 (30 - 72) | 48 (26.75 - 72) | 0.402 |
| Duration of illness | |||||
| Hospital stay (days) | 3 (1 - 12) | 4 (1 -15) | 5 (2 - 14) | 4 (1 -15) | < 0.001 |
| Disease duration (days)c | 4 (2 - 15) | 6 (3 - 18) | 6 (3 - 15) | 6 (2 - 18) | < 0.001 |
a p Values calculated using either Chi-square test or the Kruskal-Wallis test
b Cells in Stools assessed as described in methods
c Disease duration calculated by addition of history of disease and stay in hospital
d Interquartile range values in brackets unless stated