Table 3.
Detection of cases positive for single HPV genotypes (n=815) by Amplicor and Hybrid Capture 2 (hc2) stratified by HPV risk groups (defined by Linear Array (LA) and/or Line Blot Assay (LBA) test results) in women referred to ALTS for an atypical squamous cell of undetermined significance (ASCUS) Pap. Cases were attributed to HPV risk groups hierarchically as follows: HPV16 > HPV18, other carcinogenic types (HR11) > HPV66 > HPV53/67/70/82 > other HPV.
| Type | hc2 | Amplicor at 0.2 cutpoint |
p | Amplicor at 1.5 cutpoint |
p |
|---|---|---|---|---|---|
| 16 | 75/102 (73.5%) | 99/107 (92.5%) | <0.001 | 93/107 (86.9%) | <0.001 |
| 18 | 22/35 (62.9%) | 32/35 (91.4%) | 0.001 | 32/35 (91.4%) | 0.001 |
| HR11 | 216/307 (70.4%) | 294/320 (91.9%) | <0.001 | 266/320 (83.1%) | <0.001 |
| 66 | 16/26 (61.5%) | 5/27 (18.5%) | 0.001 | 0/27 (0%) | <0.001 |
| 53/67/70/82 | 39/72 (54.2%) | 18/76 (23.7%) | 0.009 | 5/76 (6.6%) | <0.001 |
| Other | 26/237 (11.0%) | 60/249 (24.1%) | <0.001 | 33/249 (13.3%) | 0.04* |
Single HPV genotype infections were determined by LA or LBA positivity. hc2: Hybrid Capture 2; HR11: Targeted carcinogenic types without HPV16 and HPV18. Differences were tested for statistical significance using an exact McNemar’s χ2 test.
*
not significant after correction for multiple testing