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The IC50 values of YQ36 and DOX on three panels of chemosensitive tumor cell line and their chemoresistance subline. The fold indicated the index of IC50 on chemoresistance subline versus chemosensitive cell line.
| Cell lines | IC50 (μM) | |||
|---|---|---|---|---|
| YQ36 | Fold | Doxorubicin | Fold | |
| KB | 5.80 ± 0.39 | 0.82 | 4.35 ± 0.16 | 6.60 |
| KB/VCR | 4.78 ± 0.66 | 28.69 ± 1.87 | ||
| MCF-7 | 15.68 ± 1.41 | 0.50 | 29.76 ± 1.48 | 4.49 |
| MCF-7/DOR | 7.90 ± 0.73 | 133.48 ± 13.95 | ||
| K562 | 5.64 ± 1.40 | 2.28 | 3.06 ± 0.04 | 4.47 |
| K562/ADR | 12.86 ± 1.97 | 13.68 ± 1.03 | ||
