Table 2.
Tissue expression modulations of the insulin/IGF system in ovarian cancer.
| Insulin/IGF components | No. of patients | Modulation | Reference |
|---|---|---|---|
| Free IGF-I mRNA and protein | 215 EOC | ↑ | [43] |
| IGF-I, IGF-IR mRNA, and several genes downstream of the receptor | 64 EOC | ↑ | [44] |
| IGF-II mRNA | 109 EOC | ↑ | [45] |
| IGF-II mRNA | 215 EOC | ↑ | [46] |
| IGFBP3 protein | 128 clear cell carcinoma | ↑ | [47] |
| IGFBP-2 mRNA | 113 EOC | ↑ | [48] |
| IGFBP-3 protein | 147 EOC | ↓ | [50] |
| IGFBP-3 protein | 35 endometrioid carcinoma | ↓ | [51] |
EOC: epithelial ovarian cancer.