Table 3.

Circulating protein levels of the insulin/IGF system in ovarian cancer.

Insulin/IGF components	No. of patients	Modulation	Reference
IGFBP-2	20 EOC	↑	[49]
IGF-I	58 EOC	↓	[53]
IGF-I	24 EOC	↓	[52]
IGF-I	59 EOC	↓	[54]
IGF-I	9 EOC	↓	[55]
IGF-I	132 EOC (<55 yrs.)	↑	[56]
IGF-I	214 EOC (<55 yrs.)	↑	[57]
IGF-I, IGFBP-2, IGFBP-3	222 EOC	↔	[58]

EOC: epithelial ovarian cancer.