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Inhibition constants of AEP, cathepsin V and trypsin by macrocypin, clitocypin and their mutants
NI, no inhibition.
| Ki AEP | Ki Cathepsin V | Ki Trypsin | |
|---|---|---|---|
| nm | nm | μm | |
| Mcp 1a | 3.38 ± 1.44 | 0.69 ± 0.06 | NI |
| Mcp 1/4 | NI | 3.43 ± 0.31 | 0.18 ± 0.02 |
| Mcp 4a | >1000 | 1.44 ± 0.11 | 0.16 ± 0.01 |
| Mcp 4/1 | 2.86 ± 0.38 | 10.2 ± 0.6 | NI |
| Mcp 4 K72R | NI | 6.9 ± 1.1 | 0.13 ± 0.02 |
| Clta | 21.5 ± 2.81 | 0.084 ± 0.03 | NI |
| Clt N70K | NI | 0.26 ± 0.09 | NI |
a Data reported previously (9).
