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. 2009 Nov 12;285(1):576–582. doi: 10.1074/jbc.M109.076216

FIGURE 3.

FIGURE 3.

NAADP-induced [Ca2+]i stimulates cADPR production by Ang II in HSCs. A, kinetics of cADPR and NAADP production by Ang II in CD38+/+ HSCs. *, p < 0.05 versus basal intracellular cADPR concentration ([cADPR]i); **, p < 0.05 versus basal intracellular NAADP concentration ([NAADP]i). B, exogenous cADPR0-mediated (10 μm) or NAADP-mediated (100 nm) [NAADP]i or [cADPR]i increase in CD38+/+ HSCs is presented in a time course. *, p < 0.01 versus basal [cADPR]i. C, Ang II-mediated cADPR production was inhibited by losartan, XeC, and a high concentration of NAADP, but not in the absence of extracelluar Ca2+. D, NAADP-induced (100 nm) increase of [Ca2+]i in HSCs. E, NAADP-evoked sustained Ca2+ increase was abolished in the presence of 8-Br-cADPR. F, Ang II-stimulated cADPR or NAADP production was measured in CD38−/− HSCs. *, p < 0.001 versus basal [cADPR]i; †, p < 0.05 versus basal [NAADP]i. Values are means ± S.E. of three independent experiments.