FIGURE 4.

Unique features of the EphA4-ephrin-B2 interclass dimerization interface. a, stereo pair comparing the conformations of the Eph receptor J-K loops in the EphA4-ephrin-B2 and EphB2-ephrin-B2 (Protein Data bank code 1KGY) complexes. A portion of the EphA4 J-K loop is moved away from Leu¹²⁷ at the tip of the ephrin-B2 G-H loop. b, surface polar contact region identified in the EphA4-ephrin-B2 complex involving EphA4 residues Gln¹² and Glu¹⁴ and ephrin-B2 residues Gln¹⁰⁹ and Lys¹¹². The region provides additional interactions besides those between the EphA4 channel and the ephrin-B2 G-H loop. Disulfide bonds are shown in yellow.