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Structures of the known Eph-ephrin complexes. The surface contact region equivalent to that observed in the EphA4-ephrin-B2 complex is shown for the EphB2-ephrin-B2 (Protein Data Bank code 1KGY) and EphB4-ephrin-B2 (code 2HLE) complex structures. The EphB2-ephrin-A5 (code 1SHW) and EphA2-ephrin-A1 (code 3CZU) complex structures lack an extensive surface contact region. The receptors are shown in red, and ephrin-B2 is shown in violet; disulfide bonds are shown in yellow.
