FIGURE 3.

Dose-related effects of increased K⁺ conductance and H⁺ conductance or diazoxide on brain mitochondrial calcium retention. Experiments were run as described in Fig. 1, and CRC is expressed as % of control (vehicle, 0.2% ethanol or DMSO). The K⁺ carrier valinomycin increased CRC at low concentrations, but a decrease was seen at the highest tested concentration. In contrast, all tested concentrations of the protonophore CCCP dose-dependently decreased CRC. The K-ATP channel opener diazoxide was without effect at 5 μm, but higher concentrations decreased CRC. The asterisk indicates significant difference compared with control.