Table 1.
Cohorts used for the study
| Region | Cohort | N pedigrees | N pedigrees MHC | Not DR3/DR4 trios | DR3/DR4 trios | Age of onset mean | s.d. | n T1D patients age of onset | Num Peds with age of onset |
|---|---|---|---|---|---|---|---|---|---|
| 1 | AP | 169 | 118 | 130 | 109 | 10.34 | 7.94 | 366 | 169 |
| 2 | DAN | 130 | 94 | 106 | 85 | 14.99 | 11.23 | 293 | 130 |
| 2 | EUR | 428 | 329 | 429 | 232 | 11.83 | 8.26 | 893 | 428 |
| 4 | HBDI | 424 | 413 | 540 | 342 | 12.28 | 8.67 | 937 | 415 |
| 4 | JOS | 71 | 53 | 56 | 52 | 11.83 | 7.53 | 148 | 71 |
| 4 | NA | 295 | 217 | 263 | 172 | 8.76 | 6.62 | 637 | 295 |
| 5 | BDA | 393 | 0 | 0 | 0 | 12.60 | 9.76 | 853 | 391 |
| 5 | SAR | 74 | 52 | 51 | 52 | 12.75 | 8.71 | 150 | 74 |
| 5 | UK | 108 | 91 | 93 | 90 | 8.22 | 5.29 | 242 | 108 |
| Total | 2092 | 1367 | 1668 | 1134 |
Abbreviations: MHC, major histocompatibility complex; T1D, type I diabetes.
Proportions of DR3/DR4 vs non-DR3/DR4 are shown, as well as average age of onset in each cohort.