Table 3.
Genetic association between TCF7 SNPs and T1D in all pedigrees regardless of MHC genotype
| Marker | Over transmitted allele | is | T:U | Trans (%) | χ2 | TDT P value | Odds ratio | 95% CI | PTDT P value |
|---|---|---|---|---|---|---|---|---|---|
| rs30503 | C | Major | 675:623 | 52.0 | 2.083 | 0.1489 | 1.08 | (0.97–1.20) | 0.0774 |
| rs30500 | C | Major | 852:800 | 51.6 | 1.637 | 0.2008 | 1.07 | (0.96–1.17) | 0.1304 |
| rs30499 | A | Major | 1125:1062 | 51.4 | 1.815 | 0.1779 | 1.06 | (0.97–1.15) | 0.1266 |
| rs244948 | G | Major | 696:679 | 50.6 | 0.21 | 0.6466 | 1.03 | (0.92–1.13) | 0.6921 |
| rs5742913 | A | Minor | 728:643 | 53.1 | 5.27 | 0.0217 | 1.13 | (1.01–1.25) | 0.0112 |
| rs244692 | A | Major | 468:439 | 51.6 | 0.927 | 0.3356 | 1.07 | (0.93–1.21) | 0.4014 |
| rs151822 | T | Major | 1088:1064 | 50.6 | 0.268 | 0.6049 | 1.02 | (0.93–1.11) | 0.4978 |
| rs152404 | C | Minor | 762:750 | 50.4 | 0.095 | 0.7576 | 1.02 | (0.91–1.12) | 0.9597 |
| rs152406 | G | Major | 311:302 | 50.7 | 0.132 | 0.7162 | 1.03 | (0.87–1.20) | 0.7808 |
| rs249611 | G | Minor | 491:488 | 50.2 | 0.009 | 0.9236 | 1.01 | (0.88–1.14) | 0.8754 |
| rs17653687 | A | Major | 868:774 | 52.9 | 5.381 | 0.0204 | 1.12 | (1.01–1.23) | 0.0066 |
Abbreviations: PTDT, parental TDT; SNP, single-nucleotide polymorphism; T1D, type I diabetes; TDT, Transmission Disequilibrium Test.
Designations for the two SNPs that showed T1D association are shown in bold. Data indicating significant association in the unstratified sample set are shown in bold.