Table 4.
Genetic association between TCF7 SNPs and T1D in trios where the affected offspring carried the HLA-DR3/DR4 genotype
| Marker | Over transmitted allele | is | T:U | Trans (%) | χ2 | TDT P value | Odds ratio | 95% CI | PTDT P value |
|---|---|---|---|---|---|---|---|---|---|
| rs30503 | G | Minor | 229:224 | 50.6 | 0.055 | 0.8143 | 1.02 | (0.85–1.22) | 0.9265 |
| rs30500 | C | Major | 268:255 | 51.2 | 0.323 | 0.5697 | 1.05 | (0.88–1.24) | 0.5498 |
| rs30499 | G | Minor | 347:335 | 50.9 | 0.211 | 0.6459 | 1.04 | (0.89–1.20) | 0.7078 |
| rs244948 | G | Major | 223:214 | 51.0 | 0.185 | 0.6668 | 1.04 | (0.86–1.25) | 0.6388 |
| rs5742913 | A | Minor | 223:207 | 51.9 | 0.595 | 0.4404 | 1.08 | (0.89–1.30) | 0.2767 |
| rs244692 | A | Major | 149:139 | 51.7 | 0.347 | 0.5557 | 1.07 | (0.85–1.35) | 0.6051 |
| rs151822 | C | Minor | 343:316 | 52.0 | 1.106 | 0.2929 | 1.09 | (0.93–1.26) | 0.421 |
| rs152404 | C | Minor | 267:233 | 53.4 | 2.312 | 0.1284 | 1.15 | (0.96–1.36) | 0.2022 |
| rs152406 | A | Minor | 102:78 | 56.7 | 3.2 | 0.0736 | 1.31 | (0.97–1.75) | 0.0784 |
| rs249611 | G | Minor | 171:148 | 53.6 | 1.658 | 0.1978 | 1.16 | (0.92–1.43) | 0.2709 |
| rs17653687 | A | Major | 270:226 | 54.4 | 3.903 | 0.0482 | 1.19 | (1.00–1.42) | 0.0263 |
Abbreviations: PTDT, parental TDT; SNP, single-nucleotide polymorphism; T1D, type I diabetes; TDT, Transmission Disequilibrium Test.
Designations for the two SNPs that showed T1D association are shown in bold. Data indicating significant association in the DR3/DR4 subset are shown in bold.