Table 5.
Genetic association between TCF7 SNPs and T1D in trios where the affected offspring did not carry the HLA-DR3/DR4 genotype
| Marker | Over transmitted allele | is | T:U | Trans (%) | χ2 | TDT P value | Odds ratio | 95% CI | PTDT P value |
|---|---|---|---|---|---|---|---|---|---|
| rs30503 | C | Major | 336:283 | 54.3 | 4.538 | 0.0332 | 1.19 | (1.01–1.39) | 0.015 |
| rs30500 | C | Major | 403:377 | 51.7 | 0.867 | 0.3519 | 1.07 | (0.92–1.23) | 0.2787 |
| rs30499 | A | Major | 546:485 | 53.0 | 3.609 | 0.0575 | 1.13 | (0.99–1.27) | 0.051 |
| rs244948 | G | Major | 335:327 | 50.6 | 0.097 | 0.7559 | 1.02 | (0.87–1.19) | 0.8487 |
| rs5742913 | A | Minor | 345:273 | 55.8 | 8.388 | 0.0038 | 1.26 | (1.07–1.48) | 0.0075 |
| rs244692 | A | Major | 223:209 | 51.6 | 0.454 | 0.5006 | 1.07 | (0.88–1.28) | 0.6053 |
| rs151822 | T | Major | 534:475 | 52.9 | 3.45 | 0.0633 | 1.12 | (0.99–1.27) | 0.0442 |
| rs152404 | T | Major | 378:335 | 53.0 | 2.593 | 0.1073 | 1.13 | (0.97–1.30) | 0.0465 |
| rs152406 | G | Major | 146:133 | 52.3 | 0.606 | 0.4364 | 1.10 | (0.86–1.38) | 0.4429 |
| rs249611 | A | Major | 241:217 | 52.6 | 1.258 | 0.2621 | 1.11 | (0.92–1.33) | 0.13 |
| rs17653687 | A | Major | 399:355 | 52.9 | 2.568 | 0.1091 | 1.12 | (0.97–1.29) | 0.0307 |
Abbreviations: PTDT, parental TDT; SNP, single-nucleotide polymorphism; T1D, type I diabetes; TDT, Transmission Disequilibrium Test.
Designations for the two SNPs that showed T1D association are shown in bold. Data indicating significant association in the non-DR3/DR4 subset are shown in bold.