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. 2009 Nov 16;53(1):221–229. doi: 10.1021/jm901059x

Table 1. Scaffold Ia.

graphic file with name jm-2009-01059x_0009.jpg

      Ki (μM)
compd R1 R2 TbPTR1 LmPTR1
MTX CH2N(CH3)C6H5CONHCH(COOH)CH2CH2COOH H 0.152 0.039
1 CH (CH3)2 CH(CH3)2 3.3 0. 24
2 C6H5 NH2 1.2 3.4
3 CH3 (CH3)2 >35 12
a

The Ki values of MTX for TbPTR1 and LmPTR1 are from ref (15).