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Pairwise structure-activity relationships for amino acids in the O9–O10 (a), O9–O11 (b), and O10-O11-positions (c). The relative size of each pie graph is proportional to the number of analogs synthesized and screened. Dark red, very high; red, high; yellow, medium; cyan, low; black, inactive antagonist potency at the α7 nAChR.
