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. 2009 Nov 2;285(3):1850–1860. doi: 10.1074/jbc.M109.023762

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FIGURE 5. — PARP activation in Survivin(dn)-expressing cells and effect of caspase inhibitor. A, flow cytometric analysis stained with annexin-V (abscissa) and PI (ordinate). UOC-B1/Survivin(dn) and REH/Survivin(dn) cells were cultured in medium containing 100 μm zinc 1 h after treatment with or without 20 μm benzyloxycarbonyl-VAD-fluoromethyl ketone (VAD), a pan-caspase inhibitor. B, UOC-B1/Survivin(dn) or UOC-B1/pMT cells were cultured in medium containing 100 μm zinc for the indicated times. Immunoblot analysis of UOC-B1/Survivin(dn) cells was performed to detect caspase-3, cleaved caspase-3, caspase-9, cleaved caspase-9, intact PARP, fragmented PARP, and α-tubulin proteins. As a positive control (C), Jurkat cells were treated with etoposide.