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Influence of CN585 and CN675 on calcineurin phosphatase activity. Calcineurin activity was measured in phosphatase assays using 33P-labeled RII phosphopeptide (A) or pNPP (B) as substrates in the presence of increasing concentrations of CN585 (closed circle) or CN675 (open circle). The data presented are the percent activity of a DMSO-containing control as means ± S.D. of three independent measurements.
