TABLE 1.

Structures of the synthesised 2,6-diaryl-substituted pyrimidine derivatives

¹ Phosphatase assay with RII phosphopeptide as substrate (S.D. ≤ 10%).

² Cytotoxicity of the 20 μm compound against Jurkat cells after 24 h of incubation (propidium iodide-permeable cells, DMSO as control; S.D. ≤ 10% of triplicates).

³ n.i., measured calcineurin inhibition at 20 μm was ≤3%.