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. 2009 Nov 10;285(3):1980–1988. doi: 10.1074/jbc.M109.016741

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FIGURE 3. — FPP blocks keratinocyte migration. A, ZGA and DEX inhibit keratinocyte migration in the wound scratch assay. EGF treatment stimulated keratinocyte migration, and after 48 h cells covered the scratch completely. When present together, ZGA blocks EGF-stimulated keratinocyte migration. The average coverage of the scratch widths in percentage is presented by the histograms. B, HEK were wounded by scratch and incubated with or without, EGF, FPP, EGF + FPP, B581, or B581 + FPP. Keratinocyte migration was monitored for 48 h. FPP shows the same inhibitory effect on keratinocyte migration as ZGA. Interestingly, treatment either with B581 alone or with FPP had the same effect, indicating that enhanced protein farnesylation mediated through increased FPP in cells does not inhibit migration. CTRL, control.