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. 2009 Nov 10;285(3):1980–1988. doi: 10.1074/jbc.M109.016741

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FIGURE 4. — FPP inhibits HEK migration, whereas mevastatin promotes it. A, DEX (1 μm) and FPP (10 μm) inhibit keratinocyte migration in the wound scratch assay. When present together, RU486 (10 μm) reverses both DEX and FPP inhibition of keratinocyte migration. B, mevastatin (MEV, 10 μm) increases keratinocyte migration in the wound scratch assay. Simultaneous treatment with FPP (10 μm) abolishes the effect of mevastatin and leads to a similar inhibition of migration as a FPP treatment alone. EGF treatment served as a positive control (CTRL) in both experiments. As expected, it stimulated keratinocyte migration. The average coverage of the scratch widths in percentage is presented by the histograms.