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. 2009 Nov 10;285(3):1980–1988. doi: 10.1074/jbc.M109.016741

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FIGURE 7. — Altering endogenous levels of FPP modulates epithelialization through inhibition of K6, whereas mevastatin reverses it. Shown is immunolocalization of K6 (green) at the wound edge and epithelial tongue after injury to epidermis in the human skin organ culture model. The white arrows indicate the initial wound edges. Mevastatin induces the expression of K6 at the wound edge. Both ZGA and FPP reduce the levels of K6 at the wound margin and inhibit epithelialization. Mevastatin reverses the effect of ZGA because of an upstream block in mevalonate pathway. The addition of exogenous FPP restores inhibition of wound healing and K6 expression.