FIGURE 2.

Interaction of pDI peptides with MDMX in atomic detail (stereo views). The peptide-binding site of the respective MDMX peptide complexes is displayed in a 4.2-Å radius around the pDI (top panel), pDI6W (middle panel), and pDIQ (chain A, bottom panel). Protein residues are shown in gray, the peptide is shown in yellow, and water molecules are presented as cyan spheres. Intermolecular hydrogen bonding (d ≤ 3.3 Å) and van der Waal's (d ≤ 4.2 Å) interactions are represented as black and green dotted lines, respectively. The purple dotted lines indicate intrapeptidic side chain/main chain hydrogen bonds.