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Inhibition of the constitutive LEF-1 responsive transactivation in SW480 cells by cadherin derivatives. (A) SW480 cells were transfected with TOPFLASH and the different cadherin constructs. The levels of β-catenin, LEF-1, and cadherins were determined by Western blotting. (B) Subcellular localization of N-cadherin (N-CAD) (a), the N-CAD tail (c), and β-catenin (b and d) in SW480 cells transfected with N-cadherin or the cadherin tail. (Bar = 10 μm.)
