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. 2009 Sep 9;29(36):11161–11171. doi: 10.1523/JNEUROSCI.3365-09.2009

Figure 4.

Figure 4.

The effect of intrathecal FA administration on pERK in Vc neurons in IANX and sham-control rats. A, Photomicrographs of pERK-LI cells (a) and NeuN-positive cells (b), merged photomicrograph of a and b (c), and high magnification of c (d) in IANX rats with intrathecal vehicle (isotonic saline) administration following high-intensity mechanical (75.8 g) stimulation of the maxillary whisker pad and those from IANX rats with intrathecal FA administration (e–h). B, Camera lucida drawings of pERK-LI cells in Vc and upper cervical spinal cord following high-intensity mechanical stimulation (75.8 g) of the maxillary whisker pad skin in IANX rats with intrathecal vehicle (isotonic saline) or FA administration. Each red dot in the drawings indicates pERK-LI cells in B. C, D, The effects of intrathecal vehicle (isotonic saline) or FA administration on the number of pERK-LI cells in Vc after high-intensity (75.8 g) (C) or low-intensity (6 g) mechanical stimulation of the maxillary whisker pad skin (D) in IANX rats. E, The effects of intrathecal vehicle (isotonic saline) or FA administration on the number of pERK-LI cells in Vc after high-intensity mechanical (75.8 g) stimulation of the maxillary whisker pad skin in sham-control rats. Arrows in Ad and Ah indicate pERK-LI cells with NeuN immunoreactivity. Ipsilateral, Ipsilateral side to IAN transection or sham operation; Contralateral, contralateral side to IAN transection or sham operation. The arrows in B indicate the Vc region where a large number of pERK-LI cells were expressed. *p < 0.05.