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. 2009 Oct 14;102(6):3492–3504. doi: 10.1152/jn.00833.2009

Fig. 10.

Fig. 10.

An unchanging Int1 firing frequency is necessary for the normal GPR regulation of the MCN1–gastric mill rhythm in the biological preparation. A: during the gastric mill rhythm, coordinately stimulating GPR (bars) and injecting hyperpolarizing current into Int1 to reduce its firing frequency (pre-GPR/Int1 hyperpolarization [hype.]: 18.1 ± 0.1 Hz; During GPR/Int1 hype.: 15.8 ± 0.2 Hz, n = 5 cycles, P = 0.002) did not prolong the retractor phase (pre-GPR/Int1 hype.: 3.9 ± 0.1 s; during GPR/Int1 hype.: 3.5 ± 0.4 s, n = 5 cycles, P = 0.19) and reduced the protractor-phase duration (pre-GPR/Int1 hype.: 2.9 ± 0.1 s; during GPR/Int1 hype.: 1.8 ± 0.1 s, n = 5 cycles, P = 8.5 × 10−5). B: in the same preparation, GPR stimulation (bar) in the absence of current injection into Int1 selectively prolonged the retractor phase without altering Int1 firing frequency (pre-GPR: 17.3 ± 0.7 Hz; during GPR: 17.7 ± 0.3 Hz, n = 5 cycles, P = 0.11). Most hyperpolarized Vm: LG, −65 mV; Int1, −54 mV.