FIG. 2.

Tetanus-induced long-term depression (LTD) at early postnatal ages (P1–P14). A: examples of the field potentials recorded in LGN during high-frequency stimulation (HFS, 1-s, 50-Hz train) of the optic tract. The bottom trace depicts an expanded epoch (see asterisk) of the above response. B: field potentials recorded at P6 and P8 before (−10 min) and after (30, 60, and 90 min) HFS. C: individual plots showing changes in the amplitude of evoked responses as a percentage of the baseline response. Responses were obtained by a single shock given once every 30 s at a stimulus intensity that evoked a response that was between one half and two thirds maximal amplitude. D: summary plot showing the mean ± SE for 18 animals between the ages of P1 and P14 in which HFS led to LTD.