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The S1P current is IP3 receptor-independent. A: the IP3 receptor blocker heparin (5 μg/ml) was included in the patch pipette for ruptured-patch voltage-clamp recordings. Before S1P application, the holding current in the heparin-perfused cells was similar to that seen in perforated patch recordings. In S1P, noisy currents develop that are similar in amplitude and appearance to S1P-induced currents recorded in the perforated-patch configuration.
