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. Author manuscript; available in PMC: 2010 Jan 11.
Published in final edited form as: Oncogene. 2009 Jul 6;28(33):2999–3007. doi: 10.1038/onc.2009.157

Figure 5.

Figure 5

Model of how Dab2 regulates Wnt/β-catenin signaling. (a) In the absence of Dab2, Axin is recruited to the LRP5/6 co-receptor, which is facilitated by dishevelled (Dvl), resulting in Axin dephosphorylation by protein phosphatase 1 (PP1) and, ultimately its degradation. Axin degradation leads to disassociation of the β-catenin destruction complex, an increase in β-catenin levels and in Wnt target gene transcription. (b) In the presence of Dab2, Axin recruitment to the LRP5–6 co-receptor is inhibited, Axin–PP1 interactions do not occur, leading to Axin and β-catenin destruction complex stabilization, and attenuated Wnt signaling.