Table 5.

Summary of the recent literature on DTI measurements in LLD. Articles in young depressed or with other co-morbidities were excluded. FA – Fractional anisotropy, an analogous measure of anisotropy to RA. IC – Internal Capsule, ECT – Electroconvulsive therapy, other abbreviations as in the text.

Reference	Number Subjects	DTI Value	Region Evaluated	Major Result
Alexopoulos et al., 2002 (45)	13	FA	Frontal ROI based	Low FA was associated with low remission rate
Taylor et al., 2004 (3)	33	FA	Frontal, Occipital, ROI based	Low FA in depressed, one ROI
Nobuhara et al., 2004 (46)	20	FA	Frontal, Temporal, CC, ROI based	Low FA in depressed, post ECT changes
Nobuhara et al., 2006 (2)	26	FA	Whole brain, ROI based	Low FA in depressed in the frontal and temporal
Bae et al., 2006 (19)	190	FA, MD	Frontal, IC, CC, ROI based	Low FA in depressed, no difference in MD
Yang et al., 2007 (35)	46	FA	Frontal, Temporal, CC, ROI based	Low FA in depressed in multiple regions
Murphy et al., 2007 (44)	51	FA	Whole brain, Voxel based	Low FA in depressed in multiple regions
Yuan et al., 2007 (36)	30	FA	Whole brain, Voxel based	Low FA in depressed in multiple regions
Alexopoulos et al., 2008 (1)	48	FA	Whole brain, Voxel based	Low FA decreased likelihood for remission