Figure 6.

Alignment of the PLA₂-like domains of mouse OC90 and Xenopus lavius OC22 with sPLA₂s. Alignments of the indicated amino acid sequences were made by using gene works software and refined manually. Shaded residues are present in at least 7 of the 11 sequences shown. These sequences represent the mammalian sPLA₂ Groups IA (human pancreatic PLA₂; ref. 37), IIA (human synovial PLA₂; ref. 38), IIC (mouse testicular PLA₂; ref. 39), V (rat testicular PLA₂; ref. 40) and X (human fetal lung PLA₂; ref. 30), and the snake venom PLA₂s, caudoxin (group II; ref. 41), myotoxin (group I; ref. 42), and β1 bungarotoxin A1 (43).The calcium-binding loop, catalytic site, and pancreatic loop (29, 30, 44, 45) are underlined. Labeled residues are numbered as in ref. 29.