Table 2.
Performance of various definitions for heart failure in derivation set (n = 300)*
| # | Heart failure criteria based on claims and laboratory data | Sensitivity | Specificity | AUC |
|---|---|---|---|---|
| 1 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR BNP ≥ 200 pg/ml | 76.29 | 74.53 | 0.754 |
| 2 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure | 68.56 | 81.13 | 0.748 |
| 3 | ≥2 heart failure encounters OR BNP ≥ 200 pg/ml | 69.59 | 79.25 | 0.744 |
| 4 | ≥2 heart failure encounters OR any hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml | 69.59 | 78.3 | 0.739 |
| 5 | ≥2 heart failure encounters OR primary hospital discharge diagnosis of heart failure | 60.31 | 85.85 | 0.729 |
| 6 | ≥2 heart failure encounters OR BNP ≥ 100 pg/ml | 76.29 | 68.87 | 0.726 |
| 7 | ≥2 heart failure encounters | 58.76 | 85.85 | 0.723 |
| 8 | ≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR any hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 200 pg/ml | 59.28 | 81.13 | 0.702 |
| 9 | ≥2 heart failure encounters AND ≥ 1 BNP ≥ 50 pg/ml OR primary hospital discharge diagnosis of heart failure OR ≥ 1 BNP ≥ 500 pg/ml | 38.66 | 90.57 | 0.646 |
| 10 | Any hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml | 40.72 | 87.74 | 0.642 |
| 11 | Any hospital discharge diagnosis of heart failure | 35.05 | 91.51 | 0.633 |
| 12 | BNP ≥ 100 pg/ml | 48.97 | 76.42 | 0.627 |
| 13 | BNP ≥ 200 pg/ml | 36.08 | 87.74 | 0.619 |
| 14 | Primary hospital discharge diagnosis of heart failure OR BNP ≥ 500 pg/ml | 24.23 | 95.28 | 0.598 |
| 15 | BNP ≥ 500 pg/ml | 20.1 | 95.28 | 0.577 |
| 16 | Any primary hospital discharge diagnosis of heart failure | 14.95 | 100 | 0.575 |
*Calculated sensitivity, specificity, and area under curve for each claim signature is compared to the Framingham definition of heart failure (i.e., meeting either two major criteria or one major and two minor criteria).