Table 3.
Baseline scores and changes from baseline in efficacy outcome measures at weeks 24, 48 and 80 [Mean (SD)].
| Measure | Baseline | Week 24 | Week 48 | Week 80 |
|---|---|---|---|---|
| N = 75 | N = 73 | N = 57 | N = 45 | |
| UHDRS Motor Score | 47.9 (15.9) | -7.4 (9.8) * | -5.6 (12.1) * | -0.2 (11.0) |
| Total Chorea | 14.9 (3.7) | -5.8 (5.0) * | -5.6 (5.5) * | -4.6 (5.5) * |
| Gait | 1.3 (0.6) | -0.1 (0.6) | 0.0 (0.7) | 0.2 (0.7) |
| Parkinsonism | 14.5 (5.7) | -0.5 (2.7) | 0.9 (4.1) | 2.1 (4.3) * |
| Barnes Akathisia | 0.2 (0.6) | 0.1 (1.0) | 0.1 (0.9) | 0.0 (0.7) |
| Hamilton | 4.1 (3.7) | -0.0 (3.8) | 0.7 (3.4) | 0.4 (3.8) |
| Functional Checklist | 18.1 (4.7) | -0.3 (2.5) | -1.1 (2.3) * | -2.6 (3.3) * |
| Independence | 75.7 (11.5) | -2.4 (7.2) * | -4.4 (6.0) * | -7.0 (8.1) * |
| Behavioral Score (freq*severity) | 6.7 (9.7) | 3.4 (14.4) * | 2.9 (9.3) * | 3.5 (14.4) |
| Weight (kg) | 72.4 (18.8) | -1.2 (4.8) * | -1.4 (7.4) | -1.7 (6.5) |
| N = 47 | N = 45 | N = 38 | N = 30 | |
| Total Functional Capacity | 7.6 (2.4) | -0.5 (1.5) * | -1.1 (1.4) * | -2.0 (2.3) * |
| Verbal | 17.2 (10.3) | -2.0 (5.6) * | -2.0 (5.8) * | -3.6 (7.9) * |
| Symbol Digit | 19.3 (11.2) | -0.3 (5.5) | -1.9 (4.7) * | -4.8 (10.3) * |
| Stroop Color | 42.6 (17.3) | -4.4 (9.5) * | -8.9 (11.4) * | -11.0 (14.8) * |
| Stroop Words | 49.8 (20.6) | -1.2 (9.3) | -7.9 (15.4) * | -9.0 (17.4) * |
| Stroop Interference | 23.2 (11.4) | -2.7 (7.1) * | -4.5 (7.0) * | -5.0 (10.4) * |
* p < 0.05 (t-test)