Table 2.
Yeast SL gene-pairs.
| Yeast | Human | Biological process |
|---|---|---|
| YMR224C | MRE11A | Single-strand and double-strand-3'-5' exonuclease activity for DNA repair and recombination. |
| YER016W | MAPRE1 | Microtubule assembling |
| YLR418C | CDC73 | PAF1 complex. Interacts with RNA pol II. Causes hyperparathyroidism-jaw tu- mor syndrome |
| YIL128W | MMS19 | Interacts with helicase subunits of NER-transcription factor |
| YNL299W | PAPD5 | Sister chromatid cohesion. Resistance to Campothecin anti-tumor agent |
| YJL115W | ASF1 | Histone chaperone |
| YJL194W | CDC6 | Initiation of DNA replication. Oncogenic activity through repression of INK4/ARF locus |
| YGL087C | UBE2V2 | Ubiquitin-conjugating enzymes without catalytic activity |
| YJL013C | BUB1 | Involved in cell cycle checkpoint enforcement. Colorectal cancer |
| YGL058W | UBE2B | Central roll in postreplicative DNA repair in eukaryotic cells |
| YKL113C | FEN1 | Removes 5' overhanging flaps in DNA repair and Okazaki fragments. Fast tumor progress |
| YGL240W | ANAPC10 | Component of anaphase promoting complex (APC), progression through mitosis and G1 phase |
| *YDL132W | CUL1 | Core component of multiple cullin-RING-based SCF which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. |
| YOL133W | RBX1 | Component of the SCF. |
| *YBR087W | RFC3 | form a complex required by DNA polymerase delta and epsilon. |
| YNL102W | POLA1 | DNA polymerase subunit. |
| *YJR068W | RFC4 | form a complex recruited by DNA polymerase |
| YDL102W | POLD1 | DNA polymerase subunit |
Human homologs of the SL gene-pairs and the biological process that they fulfill. A preliminary candidates list, where a human gene is cancer-related (in bold) and its SL partner is not known to be directly related with cancer. Asterisk symbol indicates SL partners that belong to the same cellular pathway (within-pathway model: [23]) and are essential.