Table 3.
Associations among proband subthreshold (SUB) and full syndrome (FS) conditions at T1 (Total N=1505)
| FS-Dep (n=307) |
SUB-MDD (N=394) |
FS-Bip (N=12) |
SUB-Bip (N=59) |
FS-Anx (N=123) |
SUB-Anx (N=247) |
FS-Alc (N=70) |
SUB-Alc (N=198) |
FS-Subst (N=88) |
SUB-Subst (N=87) |
FS-Con (N=40) |
SUB-Con (N=94) |
FS-ADH (N=41) |
SUB-ADH (N=86) |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FS-Dep | -- | -- | Not applic. |
2.8 (1.7–4.8) |
4.4 (3.0–6.4) |
1.8 (1.3–2.5) |
4.0 (2.5–6.5) |
2.6 (1.9–3.6) |
5.4 (3.5–8.3) |
2.1 (1.3–3.3) |
3.3 (1.8–6.3) |
3.7 (2.4–5.6) |
n.s. |
2.5 (1.6–3.9) |
| SUB- MDD |
-- | -- | Not applic. |
n.s. | n.s. |
1.9 (1.4–2.6) |
n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. |
| FS-Bip | Not applic. |
Not applicable |
-- | -- |
5.8 (1.7–19.4) |
3.7 (1.2–11.7) |
n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. | n.s. |
| SUB-Bip | 24 (7.8%) |
21 (5.3%) |
-- | -- |
6.1 (3.4–11.0) |
2.3 (1.3–4.1) |
n.s. | n.s. | n.s. | n.s. | n.s. | 2.9 (1.4–6.1) |
5.6 (2.4–13.2) |
2.3 (1.0–5.3) |
| FS-Anx | 60 (19.5%) |
36 (9.1%) |
4 (33.3%) |
19 (32.2%) |
-- | -- |
2.2 (1.1–4.3) |
n.s. | n.s. | n.s. | n.s. |
1.9 (1.0–3.5) |
2.4 (1.0–5.5) |
2.1 (1.1–3.9) |
| SUB- Anx |
73 (23.8%) |
93 (23.6%) |
5 (41.7%) |
18 (30.5%) |
-- | -- |
1.8 (1.0–3.2) |
n.s. |
1.8 (1.1–2.9) |
n.s. |
2.2 (1.1–4.5) |
1.7 (1.1–2.8) |
n.s. |
2.5 (1.5–4.0) |
| FS-Alc | 34 (11.1%) |
24 (6.1%) |
1 (8.3%) |
4 (6.8%) |
11 (8.9%) |
18 (7.3%) |
-- | -- |
45.3 (25.8–79.4) |
2.6 (1.2–5.4) |
15.4 (7.7–30.8) |
3.0 (1.5–6.0) |
3.0 (1.1–7.9) |
n.s. |
| SUB-Alc | 72 (23.5%) |
53 (13.5%) |
1 (8.3%) |
9 (15.3%) |
23 (18.7%) |
42 (17.0%) |
-- | -- |
2.7 (1.6–4.4) |
4.4 (2.8–7.0) |
2.6 (1.3–5.3) |
2.9 (1.8–4.7) |
n.s. |
2.4 (1.5–4.0) |
| FS-Subst | 48 (15.6%) |
17 (4.3%) |
2 (16.7%) |
5 (8.5%) |
12 (9.8%) |
22 (8.9%) |
42 (60.0%) |
24 (12.1%) |
-- | -- |
12.9 (6.6–25.3) |
5.4 (3.1–9.3) |
2.9 (1.2–7.1) |
n.s. |
| SUB- Subst |
29 (9.4%) |
22 (5.6%) |
1 (8.3%) |
6 (10.2%) |
8 (6.5%) |
19 (7.7%) |
9 (12.9%) |
32 (16.2%) |
-- | -- |
3.7 (1.6–8.6) |
3.2 (1.7–5.9) |
n.s. |
4.3 (2.4–7.9) |
| FS-Con | 18 (5.9%) |
11 (2.8%) |
0 (0.0%) |
3 (5.1%) |
3 (2.4%) |
12 (4.9%) |
15 (21.4%) |
11 (5.6%) |
16 (18.2%) |
7 (8.0%) |
-- | -- |
8.9 (3.7–21.6) |
5.2 (2.4–11.4) |
| SUB- Con |
43 (14.0%) |
22 (5.6%) |
1 (8.3%) |
9 (15.3%) |
13 (10.6%) |
23 (9.3%) |
11 (15.7%) |
27 (13.6%) |
20 (22.7%) |
14 (16.1%) |
-- | -- |
3.9 (1.7%8.7) |
n.s. |
| FS-ADH | 9 (2.9%) |
11 (2.8%) |
1 (8.3%) |
7 (11.9%) |
7 (5.7%) |
7 (2.8%) |
5 (7.1%) |
8 (4.0%) |
6 (6.8%) |
2 (2.3%) |
7 (17.5%) |
8 (8.5%) |
-- | -- |
| SUB- ADH |
32 (10.4%) |
23 (5.8%) |
2 (16.7%) |
7 (11.9%) |
13 (10.6%) |
27 (10.9%) |
6 (8.6%) |
22 (11.1%) |
5 (5.7%) |
16 (18.4%) |
9 (22.5%) |
8 (8.5%) |
-- | -- |
Number of cases and percentage of condition in column are given below diagonal. For example, of the 307 cases with FS MDD, 60 (19.5%) also had FS-anxiety. Odds ratios (OR) are given above diagonal and comparison group for OR is non-SUB, non-FS probands. 95% Confidence intervals are presented below odds ratios. Dep=Major Depressive Disorder or dysthymia; Bip=Bipolar disorder; Anx=Anxiety disorder; Alc=Alcohol use disorder; Subst=non-alcohol substance use disorder; Con=Conduct disorder. ADH=Attention deficit hyperactivity disorder. FS=full syndrome. SUB=subthreshold. OR that are bolded are significant at p<.05. n.s. = non-significant.