Table 4.
Subthreshold conditions predicting first occurrence of full syndrome disorders adjusting for comorbidity
| Met diagnostic criteria for Full syndrome for first time at T2–T4 | ||||||
|---|---|---|---|---|---|---|
| Depression (N=1198) |
Bipolar (N=1493) |
Anxiety (N=1382) | Alcohol Use disorders (N=1435) |
Substance disorders (N=1417) |
Cond/ASPD (N=1465) | |
| T1 subthreshold MDD |
HR = 1.6 (1.2–2.0) |
- | - | - | - | - |
| T1 subthreshold Bipolar |
HR = 1.7 (1.0–2.7) |
- |
HR = 2.4 (1.2–4.7) |
- | - | - |
| T1 subthreshold Anxiety | - | - | HR = 1.3 (0.8–2.0) |
- | - | |
| T1 subthreshold Alcohol | - | - | - |
HR = 1.5 (1.1–2.1) |
HR = 1.2 (0.8–1.9) |
- |
| T1 subthreshold Substance | - | - | - |
HR = 1.7 (1.1–2.6) |
HR = 2.9 (1.8–4.6) |
- |
| T1 subthreshold Conduct | - |
HR = 3.9 (1.6–9.4) |
HR = 1.2 (0.7–2.2) |
HR = 1.7 (1.1–2.6) |
HR = 1.9 (1.2–3.3) |
HR = 4.6 (1.5–13.8) |
| T1 subthreshold ADHD | - | - | - | HR = 1.3 (0.9–2.0) |
HR = 2.2 (1.3–3.7) |
HR = 3.9 (1.4–11.2) |
DV is developed FS diagnosis at either T2, T3, or T4 (i.e., by age 30). HR are adjusted for sex and comorbid subthreshold and full syndrome conditions that are associated with IV and DV (see text). Only HR that were significant before adjusting for comorbidity are presented. Comparison is SUB cases who developed the disorder vs. non-subthreshold, non-Full syndrome cases who developed the disorder. HR that are bolded are significant at p<.05. Shaded HR are homotypic developments. Nonshaded HR are heterotypic developments.