Table 5.
The fitted pattern mixture model; model estimates and standard errors
| Variable | Estimate (standard error) | ||
|---|---|---|---|
| Fixed effects | |||
| Intercept | 81.51 (3.32) | ||
| t0a | −5.70 (1.84) | ||
| t1b | −9.74 (2.80) | ||
| t2c | −1.53 (1.96) | ||
| tcd | −1.32 (0.11) | ||
| dose * t0a | 11.54 (3.22) | ||
| dose * t1b | −14.44 (4.59) | ||
| dose * t2c | −4.40 (3.19) | ||
| dose | −11.06 (2.79) | ||
| dose * tcd | 0.44 (0.17) | ||
| Interaction with patterns | With relapse | Relapse free | |
| t0a | −0.80 (2.76) | −0.27 (1.99) | |
| t1b | −2.10 (4.48) | −1.74 (3.24) | |
| t2c | −5.95 (3.07) | −2.32 (2.23) | |
| tcd | 0.84 (0.13) | 1.32 (0.11) | |
| dose * t0a | −6.21 (5.16) | −8.96 (3.53) | |
| dose * t1b | −9.84 (7.38) | −11.84 (5.16) | |
| dose * t2c | 0.09 (4.96) | −0.03 (3.54) | |
| dose | 8.03 (4.12) | 9.04 (2.84) | |
| dose * tcd | −0.30 (0.20) | −0.43 (0.17) | |
| Random part (variances level 2) | |||
| Intercept | 225.06 (17.19) | ||
| t0a | 125.21 (18.73) | ||
| t1b | 378.90 (34.90) | ||
| t2c | 67.16 (15.29) | ||
| tcd | 0.09 (0.01) | ||
| Residual variance | 108.51 (3.11) | ||
| Deviance | 39,626 | ||
| P-value < 0.0001 | |||
aTime dummy indicating time point at baseline
bTime dummy indicating time point at 3 months (just after chemotherapy)
cTime dummy indicating time point at 6 months
dTime variable continuous after 1 year