Table 2.
S-vitamin B12, S-folate, and S-homocysteine concentrations in relation to histomorphology in the gastric and duodenal mucosa at baseline
Gastro-duodenal histomorphology | Vitamin B 12, pmol/l | Folate, nmol/l | Homocysteine, μmol/l |
---|---|---|---|
Median (min–max) no. examined P |
Median (min–max) no. examined P |
Median (min–max) no. examined P |
|
Normal gastric mucosa without H.pylori infection | 266 (118–663) | 9.9 (2.1–35.2) | 12.2 (2.9–33.1) |
220 | 215 | 242 | |
– | – | – | |
H. pylori-associated chronic gastritis without significant atrophy of the corpus mucosa | 282 (98–789) | 9.0 (3.1–36.3) | 13.1 (4.8–35.7) |
179 | 175 | 190 | |
0.72a | 0.21a | 0.06a | |
Non-H. pylori-associated chronic gastritis without significant atrophy of the corpus mucosa | 281 (161–575) | 12.1 (5.1–30.0) | 12.0 (8.7–21.2) |
27 | 24 | 27 | |
0.86a | 0.08a | 0.50a | |
Chronic gastritis with atrophy of the corpus mucosa with or without H. pylori infection | 269 (107–497) | 9.6 (4.0–24.2) | 20.1 (10.2–50.0) |
15 | 19 | 20 | |
0.14a | 0.61a | <0.001a | |
No significant villous atrophy of the duodenal mucosa | 269 (98–789) | 9.6 (3.1–36.3) | 12.7 (2.9–50.0) |
430 | 422 | 467 | |
– | – | – | |
Villous atrophy of the duodenal mucosa (Alexander grade III to IV) | 319 (224–603) | 6.1 (2.1–12.8) | 13.9 (8.5–33.1) |
8 | 8 | 9 | |
0.16b | 0.02b | 0.47b |
a P-value from the Mann–Whitney U-test when compared to participants with normal gastric mucosa
b P-value from the Mann–Whitney U-test when compared to participants with mild or no villous atrophy of the duodenal mucosa