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U0126 does not protect heat-induced germ cell apoptosis. Apoptotic indices (number of apoptotic germ cells per 100 Sertoli cells) at stages XII–XIV in rats treated with vehicle (control), U0126, heat, or heat + U0126 show that inhibition of MAPK1/3 has no discernible effects on heat-induced germ cell apoptosis. Values are means ± SEM. Means with unlike letters are significantly (P < 0.05) different.
