Table 1.
Identification results of proteins differentially expressed between neuroblastoma monolayer and sphere cell lines
| Number | Protein | Swissprot accession number | Molecular weight (kDa) | Isoelectric point (pI) | Functional association |
|---|---|---|---|---|---|
| 1 | HSP 90-β | P08238 | 83.1 | 4.97 | Cell stress induced |
| 2 | HSC 71 | P11142 | 70.8 | 5.37 | Cell stress induced |
| 3 | Transketolase | P29401 | 67.8 | 7.58 | Hexose monophosphate pathway |
| 4 | HSP 60 | P10809 | 61.0 | 5.24 | Cell stress induced |
| 5 | Pyruvate kinase, isozymes M1/M2 | P14618 | 57.7 | 7.95 | Glycolysis |
| 6 | Adenyl CAP-1 | Q01518 | 51.5 | 8.12 | Actin monomer binding protein |
| 7 | Tubulin β-2 chain | P68371 | 49.8 | 4.79 | Microtubule component |
| 8 | Alpha enolase | P60712 | 47.0 | 6.99 | Glycolysis |
| 9 | Actin, cytoplasmic 1 | P60712 | 41.7 | 5.29 | Cell motility |
| 10 | Septin 2 | Q15019 | 40.4 | 6.15 | Cytoskelton organization |
| 11 | PSAT | Q9Y617 | 40.3 | 7.56 | De novo serine biosynthesis |
| 12 | PGAM1 | P18669 | 28.7 | 6.75 | Glycolysis |
| 13 | TPI | P60174 | 26.5 | 6.51 | Glycolysis |
| 14 | TCTP | P13693 | 19.5 | 4.84 | Microtubule/calcium binding |
| 15 | Cofilin | P23528 | 18.3 | 8.26 | Actin polymerization/depolymerization |
| 16 | Pin-1 | P62937 | 17.9 | 7.82 | Signal transduction |
| 17 | CRABP1 | P29762 | 15.4 | 5.31 | Cytoplasmic transport |
| 18 | Thioredoxin | P10599 | 11.6 | 4.82 | Antioxidant |
HSP heat shock protein, Adenyl CAP-1 adenyl cyclase-associated protein 1, PSAT phosphoserine aminotransferase, PGAM1 phosphoglycerate mutase 1, TPI triosephosphate isomerase, TCTP translationally controlled tumor protein, Pin-1 peptidyl prolyl cis-trans isomerase A, CRAB1 cellular retinoic acid binding protein 1