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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Mol Pharm. 2009 Nov–Dec;6(6):1891–1902. doi: 10.1021/mp900215p

Table 2.

Fate of nanoparticles following respiratory tract deliverya,b

Particle
type		 Lung
retention		 GI
clearance		 Blood
transit		 AM uptake Epithelial uptake Inflammation
PMP CPP− ++ ++++ ++ ++ + −
PMP CPP+ ++ +++ ++ ++ + +
PNP CPP− ++++ + + ++++ + −
PNP CPP+ ++++ + + +++ + −
a

Abbreviations: GI, gastrointestinal; AM, alveolar macrophage.

b

Scoring: −, not detected +, <10%; ++, 10–25%; +++, 26–50%; ++++, >50%