Skip to main content
. Author manuscript; available in PMC: 2010 Jan 12.
Published in final edited form as: Mol Psychiatry. 2008 Jan 29;14(4):448–461. doi: 10.1038/sj.mp.4002135

Figure 7.

Figure 7

Behavioral effects of chronic lithium treatment. Male WTand ERK1 KO mice were chronically treated with regular or lithium-containing chows for 5-week. Baseline activity was measured for 30 min in an activity box, after which the mice were given an IP injection of amphetamine (3 mg/kg, i.p.) and activity measured for an additional 30 min. (a and b) data from WT mice. No significant effects of chronic lithium treatment were detected in WT mice. (c and d) data from ERK1 KO mice. Lithium treatment did not alter baseline activity of ERK1 KO mice. Chronic lithium treatment significantly reduced amphetamine induced activity in ERK1 KO mice (F(1, 540) = 47.25; P < 0.0001).