TO901317 treatment of stroke increases synaptogenic plasticity, axonal regeneration and decreases axonal damage and NgR expression in the ischemic brain. (A) H&E staining in low magnification and eight immunostaining measurement regions in the ischemic border area. (B–E) Synaptophysin (panel B), Bielschowsky silver (panel C), NgR (panel D), and APP (panel E) expression in the ischemic border zone (IBZ) in sham-, MCAo-, and TO901317-treated MCAo mice and the quantitative data. n=8 per group.