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TO901317 increases neurite outgrowth in hypoxic PCN. Inhibition of the PI3K/Akt pathway decreased neurite outgrowth in cultured hypoxic PCNs. (A–E) TUJ1 immunostaining in cultured hypoxic PCN (1 h OGD) and treated with controls (panel A); TO901317 (1 μmol/L) (panel B); LY294002 (panel C), and TO901317 with LY294002 (panel D) and neurite outgrowth quantitative data (panel E). n=6 per group.
